Parallels between mice and yeast uncover a potentially universal aging mechanism
The SIRT1 protein long associated with age-related disease, clusters around chromosomes in the nucleus of a mouse cell. In young organisms, SIRT1 effectively doubles as a gene-expression regulator and a DNA repairer. But when DNA damage accumulates—as it does with age—SIRT1 becomes too busy fixing broken DNA to keep the expression of hundreds of genes in check. This process is so similar to what happens in aging yeast that its discoverers believe it may represent a universal mechanism of aging... [more]
Source : Technology Review
How Cells Age The Universal Mechanism Of Aging
